Disco Petri Dish, need I say more? I started with this great tutorial here on how to build a simple Physarum Slime Simulation in Niagara in Unreal Engine 4:

https://medium.com/@ganntyu1225issei/slime-mold-on-unreal-engine-4-niagara-tutorial-295cfba1b17c
 

Then I updated and built upon the nodes to take advantage of new features in UE5. Still a work in progress but the underlying simulation setup is fascinating so I thought I'd share.

Audio:
Shygirl, Club Shy, Yseult - F*Me
Everything But the Girl - Nothing Left to Lose